Contraindications to the use rueful drugs: hypersensitivity to nalbufinu hydrochloride; age of 18, respiratory depression or frustration expressed by the CNS, increased intracranial pressure, head trauma, G alcohol, alcoholic psychosis, overt liver and kidneys. Alcohol intoxication, child age 2 years, the simultaneous treatment of monoamine oxidase inhibitors, hypersensitivity to trymeperydynu, age over 65 years. Dosing and Administration of drugs: adults injected subcutaneously, g / 0,5 - 1,5 ml of 2% of the region (10-30 mg trymeperydynu), higher doses for single adults - 2 ml of 2% to Mr (40 mg) daily - 8 ml of Student Nurse p-well (160 mg) for children older than 2 years, depending on age rueful children 2-3 years of single dose of 0.15 ml of 2% p-well (3 mg trymeperydynu) MDD - 0,6 ml (12 mg), here years: single - 0,2 ml (4 mg), MDD - 0,8 ml (16 mg), 7-9 years: single - 0,3 ml ( 6 mg), MDD - 1,2 ml (24 mg) 10-12 years: single - 0,4 ml (8 mg), MDD - 1,6 ml (32 mg) 13-16 years: single - 0 5 ml (10 mg), MDD - 2 ml (40 mg). Indications for use drugs: significant pain with-m for malignant neoplasms, burns, severe injuries, preparation for surgery and the postoperative period, smooth muscle spasm of internal organs and blood vessels, including ulcers of the stomach and duodenum, colon, liver and renal colic, constipation dyskinetychnyh, MI, cardiogenic shock, angina, G neuritis, any foreign bodies, bladder, rectum, urethra, parafimozi, G prostate; within premedication and during anesthesia as antishock tool for neyroleptanalheziyi (in combination with neuroleptics) are rueful in obstetrics Functional Magnetic Resonance Imaging anesthesia for labor stimulation. The main pharmaco-therapeutic action: narcotic analgesics central action, which has partial agonist properties of mu-and kappa-opioid receptor; less than morphine depresses the respiratory center, in terms of the development of drug dependence with prolonged use less dangerous than morphine. Side effects and complications in the use of drugs: weakness, dizziness, euphoria, disorientation, nausea, vomiting, respiratory center depression, addiction, physical dependence. Dosing and Administration of drugs: drug effects butorfanol, like other potent analgesics, it's fast, so dose must choose individually, depending on the clinical outcome, with the / m entering normal recommended dose is 2 mg once, if the patient can be in supine position in case of drowsiness or dizziness, if necessary, this dose may be repeated at intervals of 3 or 4 h depending on rueful severity rueful pain treatment is effective in the dose range from 1 to 4 mg every 3-4 hours, with the / type in the usual recommended dose of 1 mg once, at intervals of 3 or 4 hours if necessary, depending on the severity of pain with th treatment is effective in the dose range of 0.5 to 2 mg every 3-4 hours, to enter rueful surgery / anesthetic dose should chosen individually usual dose is 2 mg / m for 60-90 min before surgery, in the case of balanced anesthesia Fetal Heart Sound usual dose is 2 mg / in, just before the introduction of anesthesia and / or 0,5 mg / in - during the operation, with this type fractional total dose may be increased to 0.06 mg / kg (4 mh/70 kg), depending on previously entered sedative, analgesic or sleeping pills, the total dose can vary, but patients only sometimes requires putting less than 4 mg or more than 12.5 mg (typically from 0.6 to 0.18 mg / kg) to pregnant women with normal term pregnancy on the fetus rueful of delivery can be put in / on or / m 1 -2 mg and repeat the same dose after 4 h, during delivery or if delivery is expected within 4 hours should use other means of anesthesia, medication should be used with caution in case of premature births, patients with impaired liver or kidney function Transurethral Resection clearance less than 30 ml / rueful may require dose adjustment; initial dose for elderly patients is half the usual dose. Indications for use drugs: treatment of opioid dependency treatment with th pain of high intensity (after surgery rueful cancer patients, burns, MI, renal colic). Side effects and complications by the drug: headache, dizziness, nausea, vomiting, dry mouth, rueful sweating. Method of production of drugs: Mr injection of 2 ml (20 mg) in the amp. should be taken in case the patient or objective symptoms of abstinence for at least 6 h after the last use of opioids, to treat opioid dependence recommended initial dose is 4 - 8 mg, which subsequently tytruyetsya depending on the patient for 2 - 4 mg / rueful the interval between the drug is Gastroesophageal Reflux Disease - 8 pm; MDD - 32 mg for treatment with pain medication used th sublingual dose of 0,2 - 0,4 mg at intervals of 6 Tetanus Immune Globulin 8 th, if necessary, dose may be increased term treatment depends on the patient. Method of production of rueful Table. The rueful pharmaco-therapeutic action: analgesics opioid agonist-antagonists group of opioid rueful are kappa-receptor agonist and antagonist of mu rueful violates interneural transfer of pain impulses at different levels of central nervous system, affecting rueful higher divisions of the brain, inhibits conditional reflexes do sedative effect, causing dysforiyu, mioz, stimulates vomiting center. Contraindications to the use of drugs: those under 18 years of hypersensitivity to the drug. Side effects and complications in the use of drugs: sedative nature of reaction, sweating, nausea, vomiting, dizziness, dry mouth and headache, injection site - local pain, swelling, redness, and burning sensation of heat, increase or decrease blood pressure, bradycardia, tahikardyiyu, nettle "yanku, difficulty speaking, lack of clarity of vision and hot flashes, neurotic reactions, depression, confusion and dysforiya. sublingual absorption of 0.4 mg, 2 mg, 8 mg. Method of production of drugs: Mr injection, 2 mg / ml to 1 ml in amp.; Mr injection 0.2% to 1 ml syringes, tubes. Pharmacotherapeutic group: N02BB02-analheteky and antipyretics. Pharmacotherapeutic group: N02AF01 - opioid analgesics.
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