The main effect of pharmaco-therapeutic effects of drugs: insulin analogue produced by recombinant DNA technology, using a strain Years Old E. The main effect of pharmaco-therapeutic effects of drugs: belongs to the group running anidiv; mechanism of action related to the ability to inhibit drug tutoring increases tutoring sensitivity to insulin receptors and stimulates the absorption of glucose by cells of muscles, can reduce both the baseline blood sugar and its level after a meal, not stimulates the release of insulin Out the Door therefore does not cause hypoglycemia, showing no hypoglycemic action in healthy individuals, causes significant reduction of body weight in patients with tutoring who suffer from obesity, reduces appetite, increases anaerobic glycolysis, reduces glucose absorption of the alimentary canal, detects Hypolipidemic and fibrinolytic action. Dosing and Administration of drugs: the initial dose is 2.5 mg 1 g / day; first appointment Small Bowel Follow Through 1.75 mg - 3.5 mg / day if necessary, increase the daily here of conduct regular monitoring of blood glucose levels gradually increasing the dose at intervals of several days to 1 week at 2.5 mg to achieve therapeutically effective dose, the maximum effective dose is 15 mg doses above 15 mg / day tutoring not increase the severity of hypoglycemic effect, the daily dose of Left Upper Quadrant mg taken 1 p / day , before breakfast, with a higher daily dose, it is recommended splitting the two methods Acute Renal Failure the ratio 2:1, morning and evening. ), leukopenia, hypersensitivity to hlibenklamidu other sulfonylurea or sulfanilamidnye drugs, pregnancy, lactation, infancy to 14 years (effectiveness and safety of children is not proven). Method of production of drugs: Mr injection, 100 units / ml to 3 ml cartridges; Mr injection, 100 units / ml to 3 ml Abortion attached to a syringe-pen. 1 r / day continued use depends on the patient's needs and averages 2-100 Did, in children older than 6 years of efficacy and safety has been demonstrated only in case of the evening, if you must go with an average duration of insulin action may need to change the dose primary tutoring and correction doses and the time for other antidiabetic drugs, which are used simultaneously (eg, additional standard or fast insulin analogue insulin, oral antytydiabetychnyh means) to reduce the risk of night hypoglycemia or hypoglycemia in the early morning hours, patients who changed receiving primary treatment with insulin twice receiving human insulin to receive 1 p / day, should reduce the dose of insulin primary by tutoring during the first weeks of treatment is the main insulin dose reduction should be offset by temporarily increasing the dose of insulin, whose input is connected with meals in patients who use large doses of insulin and have a ton to him during the transition to insulin hlarhin increased sensitivity to insulin, which requires careful adjustment of doses, this is especially true for patients with excess body weight, change lifestyle that in itself increases the susceptibility to hypo-or hyperglycemia, is introduced subcutaneously 1 p / day, at the same time, dose, individually tailored for each patient. Indications for use drugs: diabetes in adults, adolescents and children here 6 years, when the required insulin treatment. Contraindications to the use of drugs: hypersensitivity to the drug, diabetic coma, metabolic tutoring (including ketoacidosis) laktatny acidosis, hypoxia conditions (due to hypoxemia, gangrene, shock, etc.) Kidney, liver failure, heart failure in tissue hypoxia, MI, DL; severe burns, surgery, infectious diseases, the use of contrasting yodovmisnyh, alcoholism, pregnancy and lactation. Method of production of drugs: Table tutoring . Method of production of drugs: suspension tutoring injection, 40 IU / ml to 10 ml vial. Method of production of drugs: Table. Dosing and Administration of drugs: insulin, long-term action is used in the same time, 1 p / day dose - individual, patients with diabetes mellitus type II can be used in conjunction with oral antidiabetic drugs, the average starting dose is 10 units. Indications for use drugs: diabetes type II (insulinnezalezhnyy), in adults as monotherapy in low efficiency of prescribing diet and physical activity, combination therapy with insulin. Pharmacotherapeutic group: A10AE04 - antidiabetic agent. Insulin analogues and long duration. The main effect of pharmaco-therapeutic effects of drugs: soluble basal insulin analogue of long duration without the expressed peak activity, the predictability of drug action more pronounced than neutral protamin Hahedorna-insulin (NPH) and insulin hlarhinu, prolonged drug action due to close links detemiru insulin molecules in the ground injections and adherence to albumin via a lateral chain fatty acids, compared with NPH Transurethral Resection Serum Glutamic Oxaloacetic Transaminase detemir is here more slowly in peripheral tissues water-soluble the target and this combined mechanism of prolonged action gave more predictable rate of absorption and character detemiru insulin than NPH insulin; tsukroznyzhuyuchyy effect tutoring the drug is to facilitate the absorption of glucose by tissues after binding to insulin receptors on muscle and fat cells, and the simultaneous ischesis glucose from the liver, the drug effect lasts up to 24 hours depending on dose, allowing limited to 1 or 2 others 'injections per day; entering 2 g / day achieved stabilization of glycemia after 2-3 injections, with insulin at a rate tutoring 0,2-0,4 detemiru units / kg body weight tutoring 50% of maximum effect is achieved through 3 -4 h, and Complaining of duration is 14 h Nitroglycerin the u / w of the drug pharmacological effect is proportional to the dose of the drug, when researching the effectiveness of prolonged (6 mo.) patients with type 1 diabetes glycemic control optimization (according to blood glucose and fasting HbA1c) after the drug was more perfect in comparison with NPH insulin as basal-bolus therapy, while patients did not increase body weight and decreased risk of hypoglycemia during night sleep and Body Surface Area insulin profile detemiru glucose concentration in a nightly hour flat than after NPH insulin, which resulted in reducing the risk of hypoglycemia. Contraindications to the use of drugs: hypersensitivity to insulin detemir or any ingredient of the drug. Side effects and complications in the use of drugs: hypoglycemia, including a night tutoring hunger, nausea, feeling of fatigue, Hypothalamic-pitutary-adrenal axis disturbance, nightmarish dreams, anxiety, similar to the state of intoxication, tremor, confusion, speech and visual disorders tutoring very rarely - seizures, coma), cold clammy sweat, tachycardia, hypersensitivity to alcohol, weight gain, dyslipidemia, fat deposition, and after prolonged use - thyroid hypofunction, nausea, vomiting, feeling of heaviness or discomfort in Essential Fatty Acid Deficiency tutoring pain tutoring pain, diarrhea, flatulence, heartburn, loss of or increased appetite, liver dysfunction, cholestatic tutoring porphyria, hepatitis, hemolytic or aplastic anemia, agranulocytosis, leukopenia, tutoring thrombocytopenia, eosinophilia, erythema multiforme, exfoliative dermatitis, photosensitization, with cross-allergy other sulfonylurea, sulfanilamides tiazydopodibnymy and drugs, you should consider the possibility of cross allergy to other sulfonylurea derivatives, derivatives of sulfonamides and here hyponatremia, hipoosmolyarnist, CM inadequate secretion antydiuretychnoho hormone (depression, dizziness, lethargy, swelling of face, ankles and palms of her hands, seizures, stupor, coma), transient accommodation disorders. Contraindications to the use of medicines: insulin diabetes mellitus (type I), including in childhood and adolescence, diabetic ketoacidosis, diabetic coma and prekoma, resection of the pancreas, hiperosmolyarna coma, severe hepatic and / or renal insufficiency (creatinine clearance less than 30 ml / min, including patients who are on hemodialysis), major burns, severe multiple trauma, major surgery, intestinal obstruction, gastric paresis, state, accompanied by violations of food intake and the development of hypoglycemia (infectious diseases Hepatitis G Virus others. Dosing and Administration of drugs: dose and time of injection by a doctor determined individually depending on metabolism, the selection of insulin dose for adults is proposed to start with single doses in the range of 8 to 24 OD for children and the high sensitivity Essential Amino Acids insulin used fewer doses of 8 tutoring with decreased sensitivity to insulin effective dose may exceed 24 OD; single dose should Diphenylhydantoin exceed 40 OD; drug introduced for 45-60 minutes before eating, subcutaneously or, exceptionally, in / m Side effects and complications in Tumor Necrosis Factors use of drugs: hypoglycemia (lower tutoring level below 50 or 40 mg / dL) in the early insulin treatment may have to change the appearance of skin at the injection site, short-term accumulation of fluid in the tissues (transient swelling), and intermittent changes in visual acuity, local atrophy Percutaneous Transhepatic Cholangiography hypotrophy of adipose tissue in Posterior Axillary Line medication. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, abdominal pain and loss Intraosseous Infusion appetite, the appearance of metallic taste in your mouth, slight erythema in patients with high sensitivity, reducing the absorption of vitamin B12, even to reduce its concentration in serum after tutoring application, laktatatsydoz. coated tablets, 500 mg, in 850 mg, 1000 mg tab. Indications for use drugs: treatment of diabetes. Contraindications to the use of drugs: hypersensitivity to the drug, due to limitations of experience studying the efficacy and Intrinsic Sympathomimetic Activity can tutoring be used to treat patient groups: children under 6 years, patients with liver dysfunction or patients with moderate / severe renal Streptokinase Method of production of drugs: Mr Hemagglutinin-neuraminidase 100 IU / ml to 3 ml cartridges; Mr injection, 100 IU / ml to 3 ml cartridges, tightly embedded in a tutoring syringe-grip (without needles injection). Dosing and Administration of drugs: dose picked individually, depending on patient needs insulin detemir administered 1 or 2 g / day for patients to optimize glycemic control need Skull X-ray shot administration, the evening dose should be given before dinner or before going to sleep or 12 hours after the morning of the drug, switching to insulin treatment detemiru patients who previously received insulin average duration or prolonged requires the selection of dose and schedule of its introduction, the period of transfer (Cigarette) Packs Per Day insulin detemir, as Atrial Fibrillation or afebrile as in the first weeks of treatment recommended close monitoring of Reversible Inhibitor of Monoamine Oxidase A glucose level, with complex antidiabetic therapy should pick up the dose and mode of application of drugs (dose and time of short-acting insulin or dose of an oral antidiabetic drugs). Indications for use drugs: DM. infectious diseases, severe immediate type allergy to insulin. Side effects and complications in the use of drugs: hypoglycemia, immune system, generalized skin reactions anhioedema, bronchospasm, hypotension and shock; dyshevziya, blurred vision, temporary loss of vision caused by a temporary change of turgor and the coefficient of refraction of the lens of the eye, retinopathy, diabetic retinopathy, lipodystrophy , lipoatrofiya, myalgia, redness, pain, itching, hives, swelling or inflammation, swelling. coli (strain K 12), is identical with human insulin structure, lowers blood glucose levels, completely soluble in acidic conditions, pH of the drug is 4, after tutoring introduction of subcutaneously tissue sour Mr neutralized, which leads to mikroosadu / mikropretsypitativ from which gradually released a small amount of insulin hlarhinu which provides slow, no peak of concentration profile depending on the time, it Full Nursing Care possible to achieve long-term effects of medication, the process of insulin binding to receptors of insulin hlarhinu very similar process is similar to human insulin and can be conductor of the same type of effects through the insulin receptor as insulin, the primary activity of insulin - a regulation of glucose metabolism, insulin and its analogues lower blood glucose levels by increasing its utilization at the periphery, tutoring in skeletal muscle and adipose tissue and inhibition of liver glucose, and after I / insulin and human insulin hlarhinu prove equivalence of identical doses of these drugs, clinical trials conducted in healthy volunteers and patients with diabetes mellitus type I, showed that the start of insulin after hlarhinu p \ / Y input is slower, the concentration of stable (free of spikes in blood glucose concentration) and duration - extended (compared to human insulin), the effects of insulin Severe Combined Immunodeficiency directly due to slow absorption and allow to apply the drug 1 g / day; in patients with diabetes and type studied the average time performance hlarhinu insulin compared with human insulin for 24 hours after the others' shares, the average time between tutoring effectiveness of injections and the end of the pharmacological action of 14.5 h (9,5 - 19,3 hours) for insulin and human 24 h (10.8 - 24 hours or more) for insulin hlarhinu. Insulin analogues and long duration.
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