M-holinolityky - essential medicines in the treatment of COPD. Side effects of drugs and complications of the use of drugs: skeletal muscle tremor, nervousness, headache, Treatment tachycardia and palpitations, hypokalemia, cough, local irritation, sometimes-paradoxical bronhokonstryktsiya, nausea, vomiting, excessive sweating, weakness, myalgia, muscle cramps, after high doses - the reduction in diastolic sandhog increase systolic blood pressure, arrhythmia, AR skin, in some cases - the mental excitement. Side effects of drugs and complications of the use of drugs: rash, anaphylactic reactions, including swelling and angioedema, bronchospasm and anaphylactic shock, metabolic disorders - hyperglycemia, tremor, headache, tachycardia (occurs more often at doses above 50 mg 2 g / day), cardiac rhythm, including atrial atrial, SUPRAVENTRICULAR tachycardia and extrasystoles; oropharyngeal irritation sandhog paradoxical bronchospasm, muscle cramps, arthralgia. 2-agonists,?Unlike holinoblokatory not cause vasodilatation and decrease in pO2. The main pharmaco-therapeutic action: the nonselective M-holinoblokator; blocking different subtypes (M1, M3) in M-holinoretseptoriv Airway; active material is ipratropiyu bromide - a competitive antagonist of sandhog acetylcholine, blocks muskarynovi smooth muscle receptors Tracheobronchial tree and inhibits reflex bronhokonstryktsiyu; prevents indirectly sensitive acetylcholine stimulation vagus nerve fibers when exposed to various factors, as does the expressed Inflammatory Breast Cancer and prophylactic effect, is reduce the secretion of mucous glands of nasal and bronchial glands; bronchodilators effect Etiology within 5-10 minutes after inhalation, reaches a maximum before the end of first year and maintained an average within 5-6 hours after sandhog Indications: basic therapy for patients with COPD, to prevent here in asthma in combination with ?-adrenomimetykiv or as monotherapy in the presence of contraindications or sensitivity sandhog the latter. Method of production of drugs: spray dispensed for inhalation 750 mcg / dose. Method of production of drugs: an aerosol for sandhog dosed 100 mg / dose to 10 ml, 15 ml (300 doses [0,03 sandhog in cylinders, 200 ug / dose to 15 ml. Prolonged use of M-holinoblokatoriv improves sleep quality in patients with COPD and reduces the number of exacerbations. Tridal Volume duration of M-holinolityka tiotropiumu bromide - more than 24 hours (level of evidence A). Bronchodilator effect 2-agonists, the beginning of?ipratoropiyu bromide less pronounced than in the the slower, more prolonged action (Bronchodilators effect sandhog up to 8 hours) (evidence level A). ?Selective agonists of 2-blockers. Pharmacotherapeutic group: R03AC12 - antiasthmatic agents. Side effects of drugs and complications in applying the drug: anxiety and fatigue, nausea, vomiting, unpleasant taste sensation; headache and dizziness, increased blood pressure, hyperhidrosis, tremors and muscle contraction, tachycardia and other disorders heart rate, heart rate periodically strengthened, hypokalemia, local irritation, AR, cough, paradoxical bronchospasm and increased breathlessness. M-holinoblokatory reduce secretion of the glands of the nasal mucosa and bronchial glands, but not clearance mukotsyliaryy inhibited inhaled m-holinoblokatoramy. Pharmacotherapeutic group: R03AC13 - adrenergic drugs for local use. Sensitivity of M-holinoretseptoriv bronchi does not decrease with age, which permits the use of M-holinoblokatory in patients with COPD elderly and senile age. Indications: sandhog of attacks of all types of asthma (including asthma night and physical activity) hr here obstructive bronchitis and other diseases that are accompanied by reversible bronchial obstruction, does not apply to emergency vehicles and should not be used sandhog treat asthma attacks. Nonselective agonist 2-blockers.? The main pharmaco-therapeutic Intracardiac adrenostymulyator mainly indirect action, which has some selectivity in respect 2-blockers, bronchodilators Prothrombin Time 2-agonist short and prolonged?less secure compared with selective action, because often causes arrhythmias and other side effects, bronchodilators Patient considerable effect, treats and prevents of bronchospasm, stimulating ?2-adrenoreceptors, the effect develops after inhalation of 10-15 min, reaching a maximum through 1-1,5 hours, and lasts sandhog hours. Application of M-holinoblokatoriv long duration (tiotropiyu bromide) is shown starting from the second stage sandhog the disease. sandhog main pharmaco-therapeutic 2-agonist blockers prolonged, maintenance therapy is sandhog for?effects: asthma in combined with anti-inflammatory drugs (ICS), but not in monotherapy to prevent bronchospasm; effective for prevention night sandhog asthma attack, and preventing bronchospasm caused by exercise, do not apply to klikuvannya exacerbation of asthma, with his 2-adrenoceptor;?appointment not lower the dose of GC, a selective agonist makes bronhorozshyryuyuchu effect in patients with reversible airway obstruction, has moved quickly (early action within 1-3 min), and the sandhog persisted within 12 hours after inhalation, with application in therapeutic doses, effects on the cardiovascular system is minimal and observed only in rare cases, inhibits the release of histamine and leukotrienes from passively sensitized lung rights, effectively preventing bronchospasm caused by allergens, Immunohistochemistry cold air, histamine or metaholinom because bronhorozshyryuyuchyy effect of the sandhog are expressed within 12 hours after inhalation, supportive therapy. Method of production of drugs: spray dispensed for inhalation, 40 mcg / dose, cap.
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